The series follows a group of teenage 7th graders, including best friends Nick Birch (Nick Kroll) and Andrew Glouberman (John Mulaney), as they navigate their way through puberty with struggles like masturbation and sexual arousal all in the Westchester County suburbs of New York. Acting as over-sexualized shoulder angels are the hormone monsters: Maurice (who pesters Andrew and Matthew and occasionally Nick), Connie - the hormone monstress (who pesters Jessi (Jessi Klein) and Nick and occasionally Missy) and Mona (Thandiwe Newton). Throughout the series, the kids interact with people and objects who are often personified and offer helpful, yet confusing, advice in their puberty-filled lives including the ghost of Duke Ellington (Jordan Peele), a French-accented Statue of Liberty, a pillow capable of getting pregnant, a bar of Adderall, and even Jessi's own vulva. They seek out their destiny as puberty challenges them mentally and physically.
Nick Kroll as Nicholas Arsenio "Nick" Birch an adolescent boy living with his loving and open-minded parents
John Mulaney as Andrew Glouberman a young boy and Nick's best friend
Jessi Klein as Jessica Cobain "Jessi" Glaser a sarcastic and smart girl
Jason Mantzoukas as Jayzerian Ricflair ian "Jay" Bilzerian a brash teenage boy
Jenny Slate as Taffiny as a pharmacist a Planned Parenthood nurse, Ms. Razz, The Implant, the Fuck Gremlin, Matthew's sister, Britney, and Greg's new girlfriend, Kaitlyn
Fred Armisen as as the ghost of Antonin Scalia a bus driver, Stavros and Bob the Hormone Monster
Maya Rudolph as Connie the Hormone Monstress
Jordan Peele as the Ghost of Duke Ellington (1899 - 1974), the jazz musician whose spirit now lives in Nick's attic and sometimes offers him advice
Ayo Edebiri as Missy Foreman-Greenwald
Andrew Rannells as Matthew MacDell a flamboyantly gay student with a love of drama and spreading gossip
Richard Kind as Marty Glouberman Andrew's grumpy, overbearing, and stereotypically Jewish father, Barbara's husband and lover of scallops
Paula Pell as Barbara Glouberman Andrew's mother and Marty's wife
Seth Morris as Greg Glaser the perpetually stoned father of Jessi Glaser and the ex-husband of Shannon Glaser
Jak Knight as DeVon the ex-husband of Devin and another popular student
June Diane Raphael as Devin LeSeven a popular student at school
Jessica Chaffin as Shannon Glaser the mother of Jessi Glaser and the unfaithful ex-wife of Greg Glaser
Joe Wengert as Caleb a student, implied to be on the autism spectrum
Neil Casey as Lars a student in a wheelchair
Jon Daly as Judd Birch the dark yet caring older brother of Nick and Leah Birch, and the son of Diane and Elliot Birch
Gina Rodriguez as Gina Alvarez a very physically developed Paraguayan girl on Missy and Jessi's soccer team whose sudden pubertal development causes a stir at school
Chelsea Peretti as Cellsea Nick's sentient cell phone that he received from Leah, and "The Pill"
Kat Dennings as Leah Birch the older sister of Nick Birch and younger sister of Judd Birch
Heather Lawless as Jenna "Jay's Mom" Bilzerian Jay's mother
Gil Ozeri as Wiggles Missy's stuffed toy
Mark Duplass as Val Bilzerian an older, bullying brother to Jay Bilzerian
David Thewlis as Lionel St. Swithens a Shame Wizard and the Hormone Monsters' mortal enemy
Paul Scheer as Kurt Bilzerian another older, bullying brother to Jay Bilzerian
Nathan Fillion as Nathan Fillion
Rob Huebel as Mr. Terry Lizer a teacher at the school
John Gemberling as Tyler the Hormone Monster
Rosa Salazar as Miss Benitez a seventh grade teacher
Jack McBrayer as Pubic Hair #1
Kristen Bell as Pam a pillow Jay has a sexual relationship with
Michaela Watkins as Cantor Dina Reznick Shannon Glaser's love interest
Ali Wong as Ali a pansexual new student at Bridgeton Middle School
Natasha Lyonne as Suzette a motel pillow
Zachary Quinto as Aiden Matthew's ex-boyfriend
Jean Smart as the Depression Kitty a cat employed in the Department of Puberty
Craig Robinson as Pubic Hair #2
Thandiwe Newton as Mona Missy's British accented hormone monstress
Maria Bamford as Tito the Anxiety Mosquito
Andy Daly as as a motel pillow and the ghost of Harry Houdini
Gary Cole as Edward MacDell
Kristen Wiig as Jessi's Vagina
Julie White as Kimberly MacDell
Alia Shawkat as Roland a friend of Nick's
Bobby Cannavale as Gavin Reeves an intense Hormone Monster that Nick hopes to have Tyler replaced
Emily Altman as "Milk" a male camper
Zach Woods as Daniel a boy Leah as interested in
Harvey Fierstein as Jerome an older gay man
Julie Klausner as Cherry Marashina formerly Cheryl Glouberman, Andrew's attractive cousin in Florida
Brandon Kyle Goodman as Walter Nick's Lovebug turned hate-worm
Judd Hirsch as Lewis Glouberman Andrew's late grandfather
Carlos Alazraqui as Gustavo the male character in the book The Rock of Gibraltar
Pamela Adlon as Sonya Jessi's lovebug
John Oliver as Harry a camp counselor
Quinta Brunson as Quinta one of Missy's cousins
David Cross as Skip Glouberman Marty's brother and Andrew's uncle
Seth Rogen as Seth Goldberg
Zach Galifianakis as the Gratitoad a talking toad that expresses gratitude
Sterling K. Brown as Michael Angelo Jessi's new boyfriend
Josie Totah as Natalie a transgender camper
Lena Waithe as Lena one of Missy's cousins
Somali Rose as Missy's Overalls
Keke Palmer as Rochelle Missy's lovebug
Nasim Pedrad as Fatima the female character in the book The Rock of Gibraltar
Jess Harnell as Dwayne Johnson a depiction of the former wrestler turned actor
Carol Kane as the Menopause Banshee a banshee that represents female menopause
Mae Whitman as Tallulah Levine
Paul Giamatti as Andrew's feces an internal reprisentation of constipation within Andrew that made him develop "Poop Madness"
Maya Erskine as Misha and Izzy two seventh-graders Nick and Andrew hook up with, and the stars of their own Netflix series, Cafeteria Girls
Jemaine Clement as Simon Sex a sensitive, shroom-taking Hormone Monster
Retta as Daisy Ellington Duke Ellington's mother
Jon Hamm as a plate of Scallops in which Marty has a secret obsession
Wanda Sykes as Ghost of Harriet Tubman
Anna Konkle as Misha and Izzy two seventh-graders Nick and Andrew hook up with, and the stars of their own Netflix series, Cafeteria Girls
Martin Short as Gordie the main character of the Canadian Netflix hit, Gordie's Journey
Kristen Schaal as Bernadette "Bernie" Sanders a girl that Andrew met during skiing with Nick's family
Hugh Jackman as himself a fictitious version of the actor depicted as one of Maury's talking dicks
Rob Riggle as Sgt. Adderall
Kumail Nanjiani as himself where he was seen in a video discussing "No Nut November" during a workout routine
Adam Scott as Dylan Keating a school teacher that Andrew as infatuated with
Mark Rivers as Backup singer
Fran Gillespie as Samira
Ashley London as DNA Expert
Joel Kim Booster as Charles Lu
Chloe Fineman as Leah Birch
Crissy Guerrero as Choir Girl
Mitra Jouhari as Sorority Girl #1
Willie Garson
Brendan McKian as Ghost of Freddie Mercury
Ileen Goldsmith as Jessi Glaser - singing double
Chris Redd
Bobby Berk as Bobby Berk
Karamo Brown as Karamo Brown
Aidy Bryant as Emmy
Jon Gabrus as Movie Theater Customer
Tawny Newsome
Tan France as Tan France
Jerry Minor as Man #3
Lynn Chen
Georgie Kidder
Philip Quinaz as Tanya Alvarez
Antoni Porowski as Antoni Porowski
Piotr Michael as Siamese Twin #2
Xosha Roquemore
Anna Graves as Mrs. Albert
Jaboukie Young-White
Kristen Rivers as Sorority Girl #2
Jonathan Van Ness as Jonathan Van Ness
Max Silvestri as Jones
Marisa Lark Wallin as Reese's Wertherspoon
Karan Soni
Vea Cabral as Classmate
The average duration of each episode is 25 - 46 minutes. Country of origin: United States. Original language: English.
