The series explores the early origins of the Mexican drug war, beginning at the time when traffickers were a loose and disorganized confederation of small, independent marijuana growers and dealers. It dramatizes the creation and rise of the Guadalajara Cartel in the 1980s as Miguel Ángel Félix Gallardo (Diego Luna) unifies several plazas, or territories, in order to build an infamous drug empire. Drug Enforcement Administration (DEA) agent Kiki Camarena (Michael Peña) moves his wife and young son from California to Guadalajara to take on a new post, where he quickly learns that his assignment will be more challenging than he could ever have imagined. Following Camarena's torture and murder by the cartel, DEA agent Walt Breslin (Scoot McNairy) brings a small covert squad of operatives to Mexico to track down and punish Gallardo and his associates.
Michael Peña as Enrique 'Kiki' Camarena
Diego Luna as Miguel Ángel Félix Gallardo the leader of the Guadalajara Cartel and founder of the modern Mexican drug trade (seasons 1 - 2)
Alyssa Diaz as Mika Camarena Kiki's wife (season 1)
José María Yazpik as Amado Carrillo Fuentes Felix's partner, Neto's nephew (reprising his role from Narcos) (seasons 1-3)
Matt Letscher as Jaime Kuykendall (main seasons 1 and 3, guest season 2)
Ernesto Alterio as Salvador Osuna Nava
Alejandro Edda as Joaquín 'El Chapo' Guzmán
Fernanda Urrejola as Maria Elvira Felix's wife (seasons 1 - 2)
Teresa Ruiz as Isabella Bautista Felix's friend and associate (based on Sandra Ávila Beltrán) (seasons 1 - 2)
Aaron Staton as Butch Sears DEA agent (season 1)
Lenny Jacobson as Roger Knapp DEA agent (season 1)
Gerardo Taracena as Pablo Acosta
Julio Cesar Cedillo as Guillermo González Calderoni
Scoot McNairy as Walt Breslin DEA agent, narrator of the story (main seasons 2 - 3, recurring season 1)
Alfonso Dosal as Benjamín Arellano Félix (main seasons 2 - 3, recurring season 1)
Mayra Hermosillo as Enedina Arellano Felix
Manuel Masalva as Ramón Arellano Félix (main season 3, recurring season 1 - 2)
Miguel Rodarte as Danilo Garza
Alex Knight as Kenny (main season 2, guest season 1)
Jesse Garcia as Sal Orozco
Matt Biedel as Daryl Petsky
Jero Medina as Ossie Mejía
Alberto Zeni as Amat Palacios
Gorka Lasaosa as Héctor Luis Palma Salazar (main seasons 2 - 3, recurring season 1)
Andres Londono as Enrique Clavel
Alberto Ammann as Hélmer "Pacho" Herrera (reprising his role from Narcos) (main seasons 2 - 3, guest season 1)
Flavio Medina as Juan García Abrego
Joaquín Cosío as Ernesto "Don Neto" Fonseca Carrillo Felix's partner, Amado's uncle (season 1, guest season 2)
Tenoch Huerta as Rafael "Rafa" Caro Quintero Felix's partner (main season 1, guest season 2)
Clark Freeman as Ed Heath
Tessa Ia as Sofía Conesa
Guillermo Villegas as Sammy Álvarez
Horacio Garcia Rojas as Tomás Morlet
Yul Vazquez as John Gavin
Mark Kubr as Tony (season 1)
Jackie Earle Haley as Jim Ferguson
Mike Doyle as Thomas Buehl
Milton Cortés as Rubén Zuno Arce
Jorge A. Jimenez as Roberto "Poison" Ramos (reprising his role from Narcos) (season 1)
Wagner Moura as Pablo Escobar (reprising his role from Narcos) (season 1)
Brian Buckley as John Walker
Francisco Denis as Miguel Rodríguez Orejuela (reprising his role from Narcos) (season 1)
Viviana Serna as Guadalupe Leija Serrano ("Lupita"), wife of Héctor Luis Palma Salazar (season 2)
Juan Sebastián Calero as Navegante (reprising his role from Narcos) (season 2)
Eric Lange as Bill Stechner (reprising his role from Narcos) (season 2)
Pêpê Rapazote as José "Chepe" Santacruz-Londoño (reprising his role from Narcos) (season 1)
Jesús Ochoa as Juan Nepomuceno Guerra
Sosie Bacon as Mimi Webb Miller
Noé Hernández as Rafael Aguilar
Julián Díaz as Blackie (reprising his role from Narcos) (season 1)
Bad Bunny as Everardo Arturo "Kitty" Paez (season 3)
Matias Varela as Jorge Salcedo Cabrera (reprising his role from Narcos) (season 2)
Fermin Martinez as Juan José "El Azul" Esparragoza Moreno (seasons 1-3)
Andrés Almeida as Cochiloco
Luisa Rubino as Andrea Nuñez
Alejandro Bracho as Mr. X
Francisco Barreiro as Francisco Arellano Félix
Ivana Plantier as Abril
Edmundo Vargas as Cuco
Alessandro Borrelli as Kiki Jr.
Érick Israel Consuelo as Manny
Manuel Uriza as Carlos Hank Gonzalez
Edison Ruíz as Comandante Méndez
Jonathan Ochoa as Miguel Jr.
Emilio Guerrero as Humberto Machaín
Mauricio Isaac as The Brother
Vladimir Cruz as Juan Matta Ballesteros
Natasha Esca as Suzy
Alejandra Guilmant as Daniela
Joshua Okamoto as Manuel
Alfonso Borbolla as Marco de Haro
Pedro Giunti as Sergio Verdín
José Julián as Javier Arellano Félix
Claudio Roca as Nicolás
Eric Etebari as Jack Dorian
Sebastian Silveti as Romeo
Luis Roberto Guzmán as Falcón
Mariana Treviño as Cecilia Rosado
Rodrigo Murray as Governor Leopoldo Celis
Sebastián Buitrón as Eduardo Arellano Félix
Jorge de los Reyes as Antonio Vargas
Itza Sodi as Captain Alfredo Zavala
Christopher Stanley as Jack Lawn
Adolfo Madera as President Elect
Yuriria del Valle as Violeta Conesa
Luna Beltran as Isabel Arellano Félix
Pedro Hernández as Paco
Marilyn Uribe as Alicia María Arellano Félix
Tania Arredondo as Ana Kuykendall
Ricardo Velderrain as Sergio
Antonio López Torres as Pedro Avilés
Sinaí Segovia as Moreño
Fernanda Andrade as Alejandra
Mark Pinter as John Bell
Nat Faxon as Ted Kaye
Julián Arango as Orlando Henao
Alberto Casablanca as Rodolfo Celis
Carlos Hernan Romo as Hernán Naranjo
Israel Islas as Comandante Pavón
Bobby Soto as David Barron
Sergio Jurado as César Conesa
Luis Alberti as Verdin
Isi Rojano as Mechanic
Raúl Villegas as Pedro
Fernando Ransom de la Torre as Juan
Noah Sloan as Danny
Julia Lehman as Rita Knapp
Gustavo Navarro as Comandante Rojas
Alberto R. Ruiz as Luis
María Rojo as Alicia Arellano Félix
Jessica Lindsey as Ronnie Sears
Mauricio Núñez Nava as Néstor
Abel Jiménez as Aaron
Pamela Almanza as 25 Year Old Girl
Emiliano Clavel as Hotel Clerk
Noel León as Drunk
Tamara Guzmán as Chapo's Mom
Adriana Llabres as Ruth
Manuel Sevilla as Well Dressed Man
Francisco Calvillo as Roberto Mayén
Sam Avishay as American Soldier
Yessica Borroto Perryman as Marta
Horace Dodd as Mark Wheeler
Marc Blucas as Rick Sacks
Ari Gallegos as Hernin Naranjo
Tim Ransom as Jim Dunn
Pako Martinez as Campesino
Ethan Russell as Kershaw
Eddie Martinez as Cooper
Gerardo Moreno as Fermín Arévalo
Hugo Rocha as Sesein Guy
Roman Arabia as Chuy
Pilar Padilla as Antonia Arévalo
Quavo as Quavo
Néstor Rodulfo as Francisco Ovando
Irving Aranda as Juan
Mike Ostroski as Terrence Poppa
Elizabeth Dominguez as DEA Secretary
Max Flores as MexFed
Sandra Zellweger as Cecelia
Fabrizio Santini as Javier Contreras
Roberto Cavazos as Alex
Louis David Horné as Alex
Luis Navarro Arredondo as Gilberto
Miranda Rinaldi as Saleswoman
Alberto Trujillo as Commander
David Bernal as Comandante Cortez
Ricardo Esquerra as Mausoleum Salesman
José Luis Pérez as Omar
Alejandro Raffel as Geologist
Ricardo Silva as Sales Manager
Alberto Lomnitz as Cuauhtémoc Cárdenas
Pilar Santacruz as Mr. X Secretary
Juan Cristobal Castillo as Observer
Armando Silva as Cartel Guy #1
Federico Zapata as Patient
Alan Alarcón as Maitre D'
Jeff Grace as Alberto Radelat
Pedro Joaquín as Mexican Border Agent
Fernando Robles as Old Farmer
Girolly Gutierrez as Wilber Varela
Molly Hagan as Stella Mancuso
Eduardo Orozco as Reporter
Bernarda Trueba as Manuela
Tete Espinoza as Young Woman
Soledad Esponda as Realtor
Sabina Gadecki as Mandy Buehl
Miguel Mena as Captain Ruiz
Alan Guillen as Christopher Recinos
Alejandra Haydeè as Young Woman
Alejandro Márquez as LTD Driver
Ignacio Torre as TV News Reporter
Ana Gonzalez Bello as Felix's Secretary
Alí Rondón as Pockmarked Comandante
Paula Schut as Scarlet Buehl
Andrea Sofia Sánchez as Young Girl
Omar Ayala as Verdín's Driver
Bruno Coronel as Andrés Pineda
Marisol Gasé as Felix's Secretary
Valente Sabino as Nacho
Kerry Ardra as Investigator #1
Lalo Arredondo as Bartender
J. Downing as Bud Mullen
Rosendo Ramírez as Priest
DaJuan Johnson as Agent Morris
Luis Felipe Montoya as Army Sergeant
Brian Oblak as US Marshal
Bruno Balam as Guy #1
David Cañete as Jalisco Cop #2
Augusto Granados as MFJP Cop #1
Luis Maya as Mexican Soldier
Gary Poux as Pathologist
Eric Strong as San Diego Realtor
Bettoven Arbelaez as Main Cartel Guy
Greg Eagles as Auctioneer
Camila Puerto as Call Girl
Roxana Saucedo as Esperanza
Derek Smith as Agent Downey
Josue Arevalo Mayer as MFJP Cop #2
Armando Comonfort Santiago as Guy #2
Antonio Fortier as DFS Officer
Cuauhtli Jiménez as Guerrilla #1
Edgar Novoa as Comandante Jalisco Cop
Jorge Aranda as Tech Guy
Esteban Caicedo as Duvan
Mario Escalante as Nieves
Alexandre Lesmes as Cali Bodyguard
Víctor César Villalobos as Óscar
Alex Arenas as Mexican Driver
Juan Pablo de Santiago as Guerrilla #2
César López as Víctor Molina
Israel Salmer as Pilot
Michelle Ampudia Vieth as Clara Knapp
Marco Acosta as Sniper
Palmeira Cruz as Young Woman
Octavio Hinojosa as Sycophant 1
Ricky Gut Mad as Embassy Clerk
Baltimore Beltran as Military Guard #1
Irving Dublín as Manny
Ian Laiter Steiglitz as Billy Knapp
Norma Pablo as Nurse
Andrés Baiz as Sycophant 2
Marcos Duarte as Contractor
Danae Garcia as Young Mother
Rubén Jiménez as Captain
Maurilio Ricaño as Worker
Martín Rojas as Tijuana Police Captain
Sergio Castillo as Governor Ocaña
Daniel Damuzi as Braulio
Sergio Gutierrez as Laborer
Nicolasa Ortíz Monasterio as Jogging Woman
Daniel Rascón as Perez
Aldo Verástegui as DFS #1
David Zorrilla as Pilot
Danny Balderas as Busboy
Alan Cancino as Army 1
Clemente Dávila as Worker
Daniel Quiróz as Iván
Jorge Antonio Guerrero as Third Narco
Jake B. Miller as Agent #1
Emmanuel Aguilar as Shoeshine Man
Brionne Davis as Texas Ranger
Oscar Mejia as Felix's Bodyguard
Ian Garcia Monterrubio as Younger Boy
Jarrett Worley as DEA Interorogator
Gotzon Zuloaga as Man
Vladimir Bruciaga as Tough Narco
Paola Flores as Celis Maid
Tomihuatzi Xelhuantzin as Attorney Elevator
Rocío Canseco as Night Nurse
Izcaret de la Parra as Recepcionist
Emi Lardi Delon as Older Boy
Barry Livingston as Judge
Salvador Parra as Maitre D'
Rafael Simón as Leo Rick Rickets
Roberto Tello as AFO Driver
Christopher Friessen as Mexican Border Agent
Mario de León as Suited Man
Ron Melendez as Local Cop #1
Javier Oviedo as Military Guy 1
Orlando Pineda as Colombian Guy #1
Nicole Reyes as Manuela
Alejandro Briones as MFKP Cop #2
Joshua Dov as Local Cop #2
Diana Resendiz as The Nanny
Teresa Cedillo as Maid
Alfredo Huereca as Serafín Herrera
Andre Musich as Military Guy 4
Brandon Prado as American Soldier 1
Steven Destello as Local Cop #3
Roberto Mares as MFKP Cop #3
Katie Chan as Cashier
Rodrigo Mendoza as Priest
Juanita Arias as Claudia
Cristian Gerardo Martínez as Palma Bodyguard
Dettmar Yañez as Cop #1
Claudia Toledo as Old Housekeeper
Uriel Mendoza as Cop #1
Jonathan Laredo as Fireman
Giovani Florido as Young Cop
Jaqueline Leal as Teresa
Ricardo Mansur as Concierge
Martín Casanova as Bar Owner
Fabián Pazzo as Tapia
Danielle Coyne as Pot Smoking Girl
Chris Jai Alex as Cop
Matthew Jones as El Paso Guy #1
Scott Thomas Reynolds as El Paso Guy
Brett Edwards as El Paso PD Narc
Alejandro Furth as Ramon Salgado
Alberto Guerra
Kristen Gutoskie as Dani
Beau Mirchoff as Steve Whipple
Luis Gerardo Méndez
David Paladino as Fernie
José Zúñiga
Andrés De León as Lawyer 1
Oscar Peña as Plainclothes Detective #2 Gomez
The average duration of each episode is 45 - 69 minutes. Country of origin: United States and Mexico.
